Women’s Hormones: The Main Reason For Changes In Your Health?

Reasons for hormonal imbalance in women

Author – Motherhood Medical Team

Many changes associated with the woman’s body are related with the hormones as they play an integral part in the health of an individual. Along with ageing, there are different changes and symptoms women begin to experience, among which most of them are thought because of hormonal changes. While it is true that hormones are a changing factor of woman’s health, but not every experience is related to them. The different feelings a woman may be subjected to are largely due their life style choices, and stress. We will see the role of major hormones and their overall effects.

Estrogen Function

Two prominent hormones, estrogen and progesterone, have considerable effect on the woman’s health, like on menstruation, pregnancy or menopause. Estrogen is mainly responsible for the physical changes associated with puberty, and cholesterol control. The levels of estrogen changes during the month which is highest in the middle of menstrual cycle and lowest during the periods. Women having low levels of estrogen may suffer from less frequent menstruation, mood swings, hot flashes, difficultly in sleeping etc. In contrast, women with too much estrogen may experience weight gain, heavy or light bleeding, fatigue etc.

Progesterone Function

Progesterone on the other hands prepares the endometrium of woman for pregnancy. Women having low levels of progesterone will experience abnormal menstrual cycles or difficulty in conceiving. Testosterone also plays an important role in women where its high levels can lead to irregular menstrual cycle, more body hairs, acnes, struggle with infertility etc. Thyroid hormone can also relate with many changes where women over the age of 60 are likely to have hypothyroidism (production of less thyroid stimulating hormone) which can concur with fatigue, constipation, dry skin, weight gain, pain in the joints etc.

Therefore, hormonal changes are the reason for most of the symptoms that occur in women.

At Motherhood Hospitals, we have a team of experienced super specialists backed by the latest in infrastructure and facilities. We have the best Gynaecologist who are experts in handling complex deliveries, gynaecological needs, and other surgeries including a range of laparoscopic surgeries.

Do take an appointment with the best Gynaecology hospital at a centre closest to you. Meet with our doctors who will carry out the required investigations, diagnose the issue and recommend the most appropriate treatment, enabling you to lead an active life.

If you wish to get in touch with our doctors, please book your appointment here.

Does Menopause Have Any Effect On Mental Health?

How does Menopause affect Mental Health?

Author – Motherhood Medical Team

Hormonal changes in women during menopause are attributed to some common mental health problems. The end of menstrual cycle and reproductive life in women is called menopause where there are changes in the hormonal levels of the body which can bring about many issues. These changes during the later stage of life are related with symptoms that can last for short period, or can last for quite a while.

Menopause can cause many physical symptoms like tiredness, night sweats, insomnia, hot flashes, stress, etc. Besides, mood changes like irritability, sadness, problem in concentration, and depression are also common. It has been seen that the symptoms associated with menopause can double the chances of depression during this time. Women who may have a history with depression or anxiety, may see a recurrence in symptoms.

Role of Estrogen in Menopause

The main hormone that fluctuates and cause as many symptoms during menopause is estrogen. Estrogen levels begin to drop during this period that can bring about hormonal fluctuations affecting the brain and nervous system altogether. Due to this, mood changes are common along with physical symptoms like fatigue, memory loss, tension, etc. that can cause emotional distress.

When it comes to depression, it has been seen women with a history of clinical depression are likely to witness recurring symptoms of depression during menopause. Research also suggest that menopause is linked with increasing the symptoms of bipolar disorder, where a woman with this disorder during menopause can experience more depressive episodes as well. The hormonal changes during menopause has shown that it can trigger mental health problems including psychotic conditions.

Solution for Menopause Symptoms

The treatment options for treating mental health problems during menopause can include lifestyle changes like getting enough sleep, exercising, quit smoking, seeking support groups, etc. Besides, some medications and therapies may also be recommended.

At Motherhood Hospitals, we have a team of experienced super specialists backed by the latest in infrastructure and facilities. We have the best Gynaecologist who are experts in handling complex deliveries, gynaecological needs, and other surgeries including a range of laparoscopic surgeries.

Do take an appointment with the best Gynaecology hospital at a centre closest to you. Meet with our doctors who will carry out the required investigations, diagnose the issue and recommend the most appropriate treatment, enabling you to lead an active life.

If you wish to get in touch with our doctors, please book your appointment here.

Tips to get your body ready for pregnancy

Tips to get ready for pregnancy

Author – Motherhood Medical Team

You may be planning for pregnancy, but there may be some questions in your mind regarding how to make your body ready for it. There are some steps that if taken will give you the best possible chance of having a healthy pregnancy along with a healthy baby.

Quick fact:

Your heart actually grows during pregnancy as the blood volume increases up to 50% which makes it beat faster.

Tips to get ready for pregnancy

Here are some important steps that you can plan to undertake in order to begin your motherhood easily:

  • A preconception checkup: If you are ready to get pregnant, it is better that you schedule a preconception checkup. During this checkup, your overall health status will be reviewed along with the health history. Besides, there may some health areas where you need some improvement which can be analyzed by the doctor as well.
  • Taking folic acid supplement: Before you start conception, it is advised that you should take 400 micrograms of folic acid every day though your first trimester. The process can be started 30 days prior to conception. By taking folic acid, you are decreasing the chances of birth defects in your baby.
  • Avoid alcohol intake: Excessive drinking is prohibited when you are trying out for pregnancy, though a moderate drink is considered fine. While during pregnancy, it is better to avoid drinking as this may pose health problems for the developing fetus.
  • Cut off smoking: Smoking can lead to miscarriage or premature birth, where you should halt this activity as it can also make it difficult for you to get pregnant.
  • Eat well and exercise: Having healthy preconception diet including of whole grains, lean proteins, low fat diary can prepare your body for pregnancy. Moreover, exercising can keep your body strong and healthy.
  • Monitor your weight: A healthy weight can make your pregnancy smoother where you can easily get pregnant as well. It is better to maintain a healthy weight before trying to conceive.

At Motherhood Hospitals, we have a team of experienced super specialists backed by the latest in infrastructure and facilities. We have the best Gynaecologist who are experts in handling complex deliveries, gynaecological needs, and other surgeries including a range of laparoscopic surgeries.

Do take an appointment with the best delivery hospital at a centre closest to you. Meet with our doctors who will carry out the required investigations, diagnose the issue and recommend the most appropriate treatment, enabling you to lead an active life.

If you wish to get in touch with our doctors, please book your appointment here.

What Is The Difference Between Obstetrics And Gynaecology?

Difference between Obstetrics And Gynaecology

Author: Dr. Richa Singh MBBS, DGO, DNB

Consultant – Obstetrician & Gynaecologist at Motherhood Hospital Kharghar, Mumbai

Different between Obstetrics and Gynaecology

A branch of medicine and surgery that specializes in the care of women during pregnancy and childbirth and in the diagnosis and treatment of diseases of the female reproductive organs. It also specializes in other women’s health issues, such as menopause, hormone problems, contraception (birth control), and infertility.

OB-GYNs dispense their special care that focuses on the female reproductive health which has become a critical part in overall health being. When it comes to women’s health and reproductive care, it is considered under obstetrics and gynecology cases.

Quick Fact: The word gynaecology is derived from two Greek words, gyne which means woman or female and logia which means the study of.

Obstetrics

When it comes to obstetrics, part of the OBGYN spectrum, it is the field of medicine consisting of the care that is dispensed towards a pregnant woman and her unborn baby. Besides, it also deals with labor and delivery processes where it is ensured that mother and child get the best care post-delivery and potential complications are warded off. A person specialized in this field is referred to as obstetrician or simply OBGYN who can take care of women during and after pregnancy, while handling some critical situations, as:

  • Ectopic pregnancy
  • Fetal distress
  • Placenta issues
  • High blood pressure
  • Cesarean section
  • Episiotomy
  • Vaginal deliveries
  • Cesarean deliveries
  • Uterine rupture
  • Prolapsed cord
  • Hemorrhage
  • Miscarriage
  • Pre eclampsia

A baby can be delivered vaginally or through a cesarean section where an obstetrician is properly trained to take care of the woman during the procedures, along with handling any change that may occur during the childbirth. After the childbirth, an obstetrician also guides the mother and child towards better health to prevent any further complications.

Consulting the best obstetrician can help a woman go through the entire experience of pregnancy and delivery safely as they can guide them to better results. Obstetricians also offer other services as:

  • Fertility treatment
  • Diagnostic procedures for fetus
  • NICU care
  • Dealing with issues like postpartum depression

Gynaecology

Gynaecology part of the OBGYN spectrum deals with the care of reproductive organs i.e. overall reproductive health of a woman. A person exclusively practicing in this field is referred to as gynaecologist or simply OBGYN, who is often visited by women at the onset of puberty and also after menopause. A woman facing concerns or situations pertaining to the treatments or maintenance of health of vagina, uterus, ovaries, and fallopian tubes, along with breasts can visit the best gynaecology hospital or best gynecologist who can take care of all. Besides, women may also want to see their gynecologist for an annual checkup and pelvic exam. Along with routine checkups, a gynecologist can:

  • Perform tests like Pap along with examination of reproductive diseases
  • Provide treatment for infections, diseases or any other irregularity
  • Perform surgical procedures as hysterectomy, tubal ligation, myomectomy
  • Treat cancers of reproductive system
  • Also advise on issues relating to fertility and conception
  • Treat incontinence
  • Diagnose causes of amenorrhea and dysmenorrhea

These health professionals can be involved for longer durations throughout a woman’s life, ranging from puberty to menopause, and beyond as well.

Contraceptive counseling has great potential as a strategy to empower women who do not desire pregnancy to choose a method of birth control that she can use correctly and consistently over time, thereby reducing her individual risk of unintended pregnancy, your obstetrician and gynecologist can help you and guide you plan as well as prevent a pregnancy.

Obstetrics and gynaecology services for women’s health are provided all over India to correspond to the different needs of women’s health right from starting of menses to delivering your babies to treating any disorders related to female reproductive system.

So when it comes to women seeking a health professional during their teenage, pregnancy and rest of their life, it is better to visit the best gynecologist nearby.

At Motherhood Hospitals, we have a team of experienced super specialists backed by the latest in infrastructure and facilities. We have the best Gynaecologist specialists in Kharghar, Mumbai. We are experts in handling complex deliveries, gynaecological, and other surgeries including a range of laparoscopic surgeries.

Do take an appointment with the best Gynaecology hospital in Kharghar, Mumbai at a centre closest to you. Meet with our doctors who will carry out the required investigations, diagnose the issue and recommend the most appropriate treatment, enabling you to lead an active life.

If you wish to get in touch with Dr. Richa Singh, please book your appointment here

Learn About Gestational Diabetes

How to deal with Gestational Diabetes

Author: Dr. Kavya Krishna Kumar MBBS, FMAS, MS

Consultant – Obstetrician & Gynaecologist at Motherhood Hospitals, Alwarpet

How to deal with Gestational Diabetes

During pregnancy, the fetus and placenta produce certain hormones that make the mother resistant to the insulin produced by her own body. To compensate, the mother has to produce more insulin to maintain the blood sugar levels. When this extra insulin produced is not enough, blood sugar level rises to cause a condition called gestational diabetes.

What Is Gestational Diabetes?

A condition where a pregnant woman’s blood sugar rises is called gestational diabetes. 

Gestational diabetes is classified into two categories. The first category is class A1, which can be managed through diet and exercise. The second category is class A2. Pregnant women diagnosed with class A2 need to take insulin and other medications to keep their blood sugar level at a normal level. Although gestational diabetes goes away after delivery, it can affect your baby’s health and can raise the risk of Type 2 diabetes.

Risk factors associated with Gestational Diabetes

Gestational Diabetes Symptoms

Gestational diabetes does not have any specific symptoms. Most cases are only discovered when your blood sugar levels are tested during screening for diabetes.Some women can develop symptoms,if the sugar levels are too high ,such as..

  • You feel more thirsty than usual
  • You feel like eating more than you usually do
  • Urination is persistent and uncontrollable.
  • Tiredness

Gestational Diabetes Causes

The primary function of your pancreas is to release insulin when you eat food. Insulin is a hormone that moves glucose from the blood to the cell so that it can use for energy. Your placenta can produce a variety of hormones which produces insulin resistance leading to increase in blood glucose levels resulting in gestational diabetes.

Gestational diabetes and pregnancy are very closely associated. Here are some of the risk factors that have high chances of developing gestational diabetes:

  • Being overweight before pregnancy
  • Have a family history of diabetes
  • Prior gestational diabetes in your first pregnancy
  • Given birth to a stillborn or with birth defects
  • History of high blood pressure, high cholesterol, heart disease, or other medical complications
  • History of PCOS or PCOD or any other health disorder related to insulin.

Risk factors associated with gestational diabetes

Gestational diabetes increases the risk of having high blood pressure during pregnancy. It will ultimately affect the baby with issues like a large head which can only be delivered by caesarean section (C-section).

Other effects that gestational diabetes can have on the baby are:

  • Overweight at the time of birth (9 pounds or more)
  • Premature birth with breathing and other problems
  • If you have gestational diabetes, your baby is at a high risk of developing severe breathing issues such as respiratory distress syndrome — a condition that makes breathing difficult.
  • Baby may have low blood sugar, which can only be balanced by prompt feedings or, in some cases, intravenous glucose solution.
  • The baby may develop Type 2 diabetes later in life.

Usually, women having gestational diabetes return to regular blood sugar levels after delivery. However, 50% of women develop Type 2 diabetes. Therefore, the risk associated with gestational diabetes can be avoided with a healthy diet and maintaining reasonable body weight after delivery.

Treatment for Gestational Diabetes

Treatment for gestational diabetes must be taken as soon as you are diagnosed with it to keep you and your baby healthy, post-delivery. During this treatment, you need to:

  • Examine the blood sugar level at least four to five times a day.
  • Follow a healthy diet. Dieticians specially design gestational Diabetes diet keeping in mind the body type and condition of your pregnancy.
  • Exercise regularly.
  • Take urine tests to check for ketones (chemicals that determine whether your diabetes is under control or not)

The doctor will keep a close track of your weight and your baby’s healthy development. If required, they may give you insulin or certain other medications to keep your blood sugar normal.

Exercise and Diet for Gestational Diabetes

You can maintain the gestational diabetes blood sugar levels by taking good care of the diet and following proper exercise plans.

You need to:

  • Replace sugary snacks like ice cream, biscuits, candies and so on with natural sugars like fresh fruits. Eating fresh vegetables, fruits and whole grains in a proper proportion is highly recommended.
  • Maintain the habit of having small meals and snack meals at least twice or thrice a day.
  • Organise an exercise plan for yourself. Daily exercise can help burn excess fat.

At Motherhood Hospitals, we have a team of experienced super specialists backed by the latest in infrastructure and facilities. We have the best experts in Alwarpet, Chennai. We are experts in handling complex deliveries, gynaecological, and other surgeries including a range of laparoscopic surgeries.
Do take an appointment with the best Gynaecology hospital in Alwarpet, Chennai at a centre closest to you. Meet with our doctors who will carry out the required investigations, diagnose the issue and recommend the most appropriate treatment, enabling you to lead an active life.

If you wish to get in touch with Dr. Kavya Krishna Kumar, please book your appointment here.

Role Of Laparoscopic Surgery In Gynaecological Cancer Treatment

Author: Dr. Kavya Krishna Kumar (MBBS, FMAS, MS),

Consultant – Obstetrician & Gynaecologist at Motherhood Hospital Alwarpet, Chennai

Ovarian Cancer

Today, the ever-changing lifestyle of women have increased their chances of many health diseases, especially cancer. The most common cancer type found in woman’s breast, cervical, lung and gynaecological cancers. Most of the abnormal vaginal discharges, abnormal vaginal bleeding, feeling of bloating, heaviness, loss of appetite, distention of abdomen, however, if ignored, can cause health issues as bad as cancer. Therefore, it is very important to bring it up to the doctor if you notice these symptoms for a prolonged period of time.

It is very important to notice the initial symptoms of cancer and get it cured, since it is in the initial stages of detection and treatment that one can defeat cancer.

Gynaecological Cancer

Gynaecological cancer is very common in women these days, affecting almost 25% of women in India. Gynaecological cancer affects the reproductive system of women. The nature and intensity of cancer depends on the part it is developed in and at what stage it is diagnosed.

Types Of Gynaecological Cancers

There are five types of gynaecological cancers. These are as follows:
  • Cervical cancer: This type of cancer starts in the cervix, also known as the neck of the womb. When there is an abnormal proliferation of cells, cervical cancer occurs.
  • Womb cancer: The womb, also known as the uterus, is a muscular bag that is pear-shaped. Once the fetus is implanted, the role of the uterus is to nurture the implanted fetus. When there is an abnormal division in the lining of the womb, it is termed uterine or endometrial cancer.
  • Ovarian cancer: The development of cancer in the ovary is ovarian cancer. When there is a rapid increase of the cell in an uncontrollable manner in the ovary, it is ovarian cancer.
  • Vaginal cancer: Vaginal cancer is usually a very rare condition. It occurs when the cells in the vagina start to increase rapidly. It is very common to occur in older women.
  • Vulval cancer: Vulval cancer occurs when the cancer cells start to develop in the external female sex organ called the vulva.

Understanding Laparoscopic Surgery

Laparoscopic surgery is a specialised technique of surgery with minimal invasion of the body. It is done with a specially designed thin, long tube called a laparoscope. It has a very high-resolution camera and high-intensity light. Once the laparoscope is inserted into the body through a small incision in the abdominal wall, it starts sending images to a video monitor. The surgery is performed with the help of these video images.

Laparoscopic Surgery’s Role In Gynaecological Cancer

Treatment Laparoscopy surgery is low-risk, has minimal invasion of the body and requires very small incisions. Laparoscopic surgery is a brief surgery and requires only 2-3 days of rest in the hospital. Generally, patients recover from laparoscopic surgery within a week and can resume their daily routine. Gynaecological cancer treatments now include laparoscopic procedures as well. Generally, the surgery is performed for all small size cervical cancers and ovarian cancers and also for endometrial cancers. Laparoscopic surgery is also performed for borderline and benign tumours. Laparoscopic Surgery In The Treatment Of Ovarian Cancer Although ovarian cancer is a scary experience, it can be treated with the laparoscopic treatment in select cases. In cases that are advanced, laparoscopy is required for confirming the diagnosis and to determine receptibility and 2nd look laparoscopy. Laparoscopic Surgery in the Treatment of Uterine Cancer or Endometrial Cancer Laparoscopic surgery can treat almost 95% of the uterine cancers with the help of total laparoscopic hysterectomy with bilateral salpingo-opherectomy (TLHBSO) and retroperitoneal lymph nodes removal (RPLND).

At Motherhood Hospitals, we have a team of experienced super specialists backed by the latest in infrastructure and facilities. We have the best fetal medicine specialists in Alwarpet, Chennai. We are experts in handling complex deliveries, gynaecological, and other surgeries including a range of laparoscopic surgeries. Do take an appointment with the best fetal medicine specialists in Alwarpet, Chennai at a centre closest to you. Meet with our doctors who will carry out the required investigations, diagnose the issue and recommend the most appropriate treatment, enabling you to lead an active life.

If you wish to get in touch with Dr. Kavya Krishna Kumar, please book your appointment here.

Why PCOS is on the rise among Indian women

Rise of PCOS in Indian women and Explore causes and effective management PCOS - Motherhood Hospital India

There is a general lack of awareness regarding the condition and it often remains undetected for years.

One in every 10 women in India has polycystic ovary syndrome (PCOS), a common endocrinal system disorder among women of reproductive age, according to a study by PCOS Society. And out of every 10 women diagnosed with PCOS, six are teenage girls.

PCOS was described as early as 1935. However, even today there is a general lack of awareness regarding the condition in India and it often remains undetected for years. This health condition is estimated to affect about 10 million women globally.

A study conducted by the department of endocrinology and metabolism, AIIMS, shows that about 20-25 per cent of Indian women of childbearing age are suffering from PCOS. While 60 per cent of women with PCOS are obese, 35-50 per cent have a fatty liver. About 70 per cent have insulin resistance, 60-70 per cent have high level of androgen and 40-60 per cent have glucose intolerance.

In studies conducted in South India and Maharashtra, prevalence of PCOS was reported as 9.13 per cent and 22.5 per cent, respectively.

Many aspects of the disorder are not understood properly as its symptoms and severity vary greatly. Women with PCOS are often found to have higher than normal insulin levels. Insulin is a hormone thatŸ??s produced in the pancreas. It helps the body cells turn sugar (glucose) into energy.

If you don’t produce enough insulin, your blood sugar levels can rise. This can also happen if you’re insulin resistant, meaning you aren’t able to use the insulin you do produce effectively. If you’re insulin resistant, your body may try to pump out high levels of insulin in an effort to keep your blood sugar levels normal.

Too-high levels of insulin can cause your ovaries to produce more androgens, such as testosterone. Insulin resistance may also be caused by having a body mass index above the normal range. Insulin resistance can make it harder to lose weight, which is why women with PCOS often struggle with this issue.

The incidence of PCOS among women and teenage girls has risen to such an extent that the Indian Council of Medical Research (ICMR) has taken up a nationwide survey. The reason it is dangerous is that if this condition is left unchecked or undiagnosed, it can lead to infertility among other long-term health concerns.

Early diagnosis and treatment is key to help prevent health problems. At Motherhood Hospitals alone, we have seen 4-5 cases of teenage girls suffering from PCOS, which is significantly high compared to 10 years ago. This is mostly due to unhealthy lifestyles, unhealthy diets and lack of exercise.

Spectrum of symptoms

Girls and women suffering from PCOS exhibit a range of symptoms such as weight gain, fatigue, unwanted hair growth, thinning hair, infertility, acne, pelvic pain, headaches, sleep problems and mood changes. Most symptoms begin shortly after puberty and they can also develop during late teens and into early adulthood.

Girls with PCOS typically have irregular periods or amenorrhea, and heavy or scanty bleeding during menses. Doctors also look for elevated levels of the male hormone androgen (testosterone) and polycystic ovaries.

With PCOS, women can develop cysts due to ovaries not being released on time. The follicles keep growing and form multiple cysts, which appear like a string of pearls. Women are likely to develop PCOS if their mother or sister also has the condition.

Not just that, women with PCOS have a higher risk of developing other health complications such as hypertension, high cholesterol, anxiety and depression, sleep apnea, heart attack, diabetes and endometrial, ovarian and breast cancer. Women who have PCOS have a higher rate of miscarriage, gestational diabetes, and premature delivery.

Recommended treatment

Unfortunately, PCOS cannot be cured. It can, however, be managed to a large extent by controlling symptoms. Exercise and a healthy diet are the best bet for women with PCOS as this will help to regulate their menstrual cycle and lower blood glucose levels.

High-fibre foods can help combat insulin resistance by slowing down digestion and reducing the impact of sugar on the blood. This may be beneficial to women with PCOS. Great options for high-fibre foods include broccoli, cauliflower and sprouts, red leaf lettuce, green and red peppers, beans and lentils, tomatoes, spinach, almonds and walnuts, olive oil, fruits, such as blueberries and strawberries, and fatty fish high in omega-3 fatty acids, such as salmon.

Lean protein sources like tofu, chicken and fish don’t provide fibre but are filling and a healthy dietary option for women with PCOS.

Instead of three big meals they should have five small meals, which helps metabolise food and in maintaining weight.

If women with PCOS are suffering from infertility, then fertility drugs may be administered to aid ovulation. On the other hand, if a woman does not want to get pregnant, then birth control pills may be prescribed.

In order to stop excess hair growth and help reduce acne, using anti-androgens is the recommended course of action. While many women have been recommended to regularly exercise, (minimum 45 minutes a day, five times a week) one refrain that we commonly hear is that they don’t have time.

Up to 5-10 per cent of weight loss will help improve the symptoms, hormonal balance and regularisation of menstrual cycle. PCOS among women, especially adolescents, is an urgent public health problem that needs careful assessment, timely intervention and appropriate treatment.

Promotion of healthy lifestyles, the need for regular exercise and increased awareness programmes on PCOS is the need of the hour to enable a holistic solution to this problem.

Authored By :Dr SUNITHA P SHEKOKAR

Press Coverage:http://bit.ly/2ok4dU7

Recurrent Pregnancy Loss by Dr. Sireesha Reddy

Recurrent Pregnancy Loss

Spontaneous pregnancy loss is a surprisingly common occurrence. Whereas approximately 15% of all clinically recognized pregnancies result in spontaneous loss, there are many more pregnancies that fail prior to being clinically recognized. Only 30% of all conceptions result in a live birth

Spontaneous pregnancy loss can be physically and emotionally taxing for couples, especially when faced with recurrent losses. Recurrent pregnancy loss (RPL), also referred to as recurrent miscarriage or habitual abortion, is historically defined as 3 consecutive pregnancy losses prior to 20 weeks from the last menstrual period. Based on the incidence of sporadic pregnancy loss, epidemiologic studies have revealed that 1% to 2% of women experience recurrent pregnancy loss.

CAUSES

Genetic Etiology

Approximately 2% to 4% of RPL is associated with a parental balanced structural chromosome rearrangement, most commonly balanced reciprocal or Robertsonian translocations.

Anatomical Abnormalities

Anatomic abnormalities account for 10% to 15% of cases of RPL and are generally thought to cause miscarriage by interrupting the vasculature of the lining of womb, prompting abnormal and inadequate placentation. Thus, those abnormalities that might interrupt the vascular supply of the lining of womb are thought to be potential causes of RPL. These include congenital uterine anomalies, intrauterine adhesions, and uterine fibroids or polyps.

The uterine septum is the congenital uterine anomaly most closely linked to RPL, with as much as a 76% risk of spontaneous pregnancy loss among affected patients. Other M?ªllerian anomalies, including unicornuate, didelphic, and bicornuate uteri have been associated with smaller increases in the risk for RPL.

The presence of intrauterine adhesions, sometimes associated with Asherman syndrome, may significantly impact placentation and result in early pregnancy loss. Intramural fibroids larger than 5 cm, as well as submucosal fibroids of any size, can cause RPL.

Infectious Causes

Certain infections, including Listeria monocytogenes, Toxoplasma gondii, rubella, herpes simplex virus (HSV), measles, cytomegalovirus, and coxsackieviruses, are known or suspected to play a role in sporadic spontaneous pregnancy loss. However, the role of infectious agents in recurrent loss is less clear. The most pertinent risk for RPL secondary to infection is chronic infection in an immunocompromised patient.

Endocrine Causes

Luteal phase defect (LPD), polycystic ovarian syndrome (PCOS), diabetes mellitus, thyroid disease, and hyper prolactinemia are among the endocrinologic disorders implicated in approximately 17% to 20% of RPL.

Poorly controlled type 1 diabetes mellitus is also associated with an increased risk of spontaneous abortion. Evaluation of endocrine disorders should include measurement of the thyroid-stimulating hormone (TSH) level. Other testing that might be indicated based on the patientŸ??s presentation include insulin resistance testing, ovarian reserve testing, serum prolactin in the presence of irregular menses, antithyroid antibody testing. Therapy with insulin-sensitizing agents for the treatment of RPL that occurs in the presence of PCOS has recently gained popularity.

Thrombotic Etiologies

Both inherited and combined inherited/acquired thrombophilias are common, with more than 15% of the white population carrying an inherited thrombophilic mutation.

The potential association between RPL and heritable thrombophilias is based on the theory that impaired placental development and function secondary to venous and/or arterial thrombosis could lead to miscarriage. Evidence that the transfer of nutrition from the maternal blood to the fetal tissues depends on uterine blood flow, and thus may be affected by thrombotic events occurring there, suggests a role for thrombophilias in pregnancy losses regardless of gestational age.

Appropriate therapy for heritable or acquired thrombophilias should be initiated once the disorder is diagnosed. Therapy is disorder specific and includes

(1) Supplemental folic acid for those patients with hyperhomocysteinemia

(2) Prophylactic anticoagulation in cases of isolated defects with no personal or family history of thrombotic complications

(3) Therapeutic anticoagulation in cases of combined thrombophilic defects.

Environmental Etiologies

Because of its propensity to result in feelings of responsibility and guilt, patients are often particularly concerned about the possibility that environmental exposures may have caused their pregnancy losses.

Three particular exposures-smoking, alcohol, and caffeine-have gained particular attention, and merit special consideration given their widespread use and modifiable nature. Although maternal alcoholism (or frequent consumption of intoxicating amounts of alcohol) is consistently associated with higher rates of spontaneous pregnancy loss, a connection with more moderate ingestion remains tenuous. Studies linking moderate alcohol intake with pregnancy loss have shown an increase in risk when more than 3 drinks per week are consumed during the first trimester or more than 5 drinks per week are consumed throughout pregnancy. It seems logical that cigarette smoking could increase the risk of spontaneous abortion based on the ingestion of nicotine, a strong vasoconstrictor that is known to reduce uterine and placental blood flow. However, the link between smoking and pregnancy loss remains controversial, as some, but not all, studies have found an association. Although still not undisputed, there appears some evidence that caffeine, even in amounts as low as 3 to 5 cups of coffee per day, may increase the risk of spontaneous pregnancy loss with a dose-dependent response. The association of caffeine, alcohol, and nicotine intake with recurrent pregnancy loss is even weaker than their associations with sporadic loss.

Prognosis

Although the diagnosis of RPL can be quite devastating, it can be helpful for the physician and patient to keep in mind the relatively high likelihood that the next pregnancy will be successful. A particular individualŸ??s prognosis will depend on both the underlying cause for pregnancy losses and the number of prior losses. Correction of endocrine disorders, APA, and anatomic anomalies enjoy the highest success rates, approximately 60% to 90%. Patients with a cytogenetic basis for loss experience a wide range of success (20%Ÿ??80%) that depends on the type of abnormality present. Overall, the prognosis for RPL is encouraging. Even with the diagnosis of RPL and as many as 4 to 5 prior losses, a patient is more likely to carry her next pregnancy to term than to have another loss.

By

Dr. Sireesha Reddy | Know your doctor